Receiving grants from the Swedish Research Council is seen as a mark of quality and an important step in advancing an independent research group. Recently, six MultiPark researchers were awarded funding for their projects, including Oxana Klementieva and Niklas Mattsson-Carlgren, who received the prestigious consolidator grants.
Congratulations to:
Oxana Klementieva for her project “Structural Mapping of Amyloid Polymorphs in Alzheimer’s Disease: Linking Structural Variants to Clinical Phenotypes”
This project explores how tiny differences in the structure of disease-linked amyloid proteins influence how the brain reacts, from triggering nerve cell damage to activating immune cells. Using cutting-edge biophotonics combined with multiplex immunofluorescence, the team studies these protein structures directly in brain tissue to understand their biological impact.
“Structural variations may explain why Alzheimer’s disease appears in different forms and progresses differently among patients. We also investigate why certain amyloid forms resist clearance, offering vital clues for developing more effective treatments,” says Oxana Klementieva.
Niklas Mattsson-Carlgren for his project “Identification and prognostication of pre-symptomatic Alzheimer's disease using blood-based biomarkers”
Treatment opportunities for Alzheimer’s disease are expanding, with new therapies targeting the core brain changes underlying the disease. Emerging drugs and diagnostics may enable intervention even during pre-symptomatic stages. This project investigates efficient multi-modal ways to identify patients most suited for very early intervention to slow disease progression, delivering major benefits for patients, families, and society.
“We develop methods to find those who are most likely to benefit from early intervention, improving individual chances to ward off cognitive impairment,” explains Niklas Mattsson-Carlgren.
Vivien Horvath for receiving the prestigious starting grant for her project “Transposable elements in the aging human brain: Functional insights and therapeutic opportunities”
In this project, Vivien Horvath’s team will investigate age-related molecular and functional changes in the human brain, with a particular emphasis on oligodendrocytes and the role of mobile genetic elements in these processes.
“By deepening our understanding of how these mobile genetic elements contribute to brain aging, we hope to pave the way for the development of targeted therapies for age-related disorders that affect oligodendrocyte function,” says Vivien Horvath.
Tomas Deierborg for his project “New Insights into Microglial Communication and Treatment: Opportunities in Alzheimer's Disease”
Niklas Marklund for his project “Novel mechanisms of brain trauma-induced dementia- and their possible prevention”
Karsten Ruscher for his project "Metabotropic glutamate receptor 5 signaling in stroke recovery"
See the complete list of awarded projects from the Swedish Research Council.
