The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Experimental Neuroinflammation Laboratory

Our research

Our projects focus is to investigate the role of neuroinflammation in neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease and stroke.

Microglia are the major immune cells in the brain. Therefore, the majority of our projects aim to explore the function of these cells and to determine how they contribute to health and disease. In addition, we investigate how lifestyle-related factors, such as physical inactivity and stress, affect neuroinflammation and contribute to brain pathology.

Our research ranges from utilizing experimental models, such as in vitro microglia and in vivo mouse models, to conducting epidemiological investigations on the Swedish population. We combine traditional immunohistochemistry, ELISA, western blot, and animal behavioral tests with novel methods such as transcriptomics, proteomics, bioinformatics, and infrared spectroscopy.

Aims

  • To elucidate the function of microglia-related genes and proteins, to find novel therapeutic targets.
  • To understand how microglial cells interact with other cells in the brain.
  • To identify early signs of neuroinflammation in neurodegenerative disorders.
  • To investigate how systemic inflammation affects neuroinflammation.
  • To clarify how lifestyle factors affect neuroinflammation and progression of disorders affecting the brain.

Impact

Understanding the role of neuroinflammation in neurodegenerative disorders opens up new therapeutic possibilities for early intervention and preventive strategies for patients at high risk of developing these diseases.

How our research contributes to the goals of MultiPark

Our projects aim at elucidating the early molecular and cellular mechanisms of pathogenesis in Alzheimer’s disease and microglia-related mechanisms in Parkinson’s disease. We address the aims of MultiPark's working group 1. 


Research Team & Publications

Read about publications and research team members of the Experimental Neuroinflammation Laboratory research group in the LU Research Portal. 

Outreach

2020

Skiers had lower incidence of depression and vascular dementia – but not Alzheimer’s Lund University news 

A New Study Shows Hitting the Slopes Could Lower Your Risk of Depression and Dementia Men's journal

Skiing is good for the soul. And brain Recreati

Cross-country skiers suffer less depression and dementia Healthmedecinentral 

January blues: cross-country skiers hold clues to beating it The Conversation

Seasonal Depression Can Be Especially Difficult for Entrepreneurs. Here's How to Fight It Inc

Long-Distance Skiers May Have "Motor Reserve" that Can Delay Onset of Parkinson's Disease Journal of Parkinson's disease

Long-Distance Skiers May Have "Motor Reserve" that Can Delay Onset of Parkinson's Disease IOS Press

Skiers Study Suggests Fitness May Stave Off Parkinson's HealthDay


2019

Researchers block protein that plays a key role in Alzheimer's disease World Pharma News

New Study: Skiing Can Lower Your Risk of Anxiety, Depression, and Dementia Snow Brains

New Study: Skiing Can Lower Your Risk of Anxiety, Depression, and Dementia Med India

Skiers Have Lower Incidence Of Depression And Vascular Dementia -- But Not Alzheimer's Dove Med

Skiing Cuts Vascular Dementia Risk in Half Alzheimer's & Dementia weekly

Skiers had lower incidence of depression and vascular dementia—but not Alzheimer’s Loire net

Study Shows Skiers Less Likely To Be Diagnosed With Depression And Vascular Dementia Mental daily

Skiing the road to a healthier aging brain Eminetra


2015

New findings on 'key players' in brain inflammation Science Daily

Microglia Kick Off Inflammatory Chain Reaction Alzforum

New findings on 'key players' in brain inflammation Technology Networks 

Profile Photo of Tomas Deierborg.

Tomas Deierborg

Professor

tomas [dot] deierborg [at] med [dot] lu [dot] se

Link to Tomas Deierborg's profile in the LU Research Portal

Homepage: https://www.neuroinflammation.lu.se 

Twitter: @TDeierborg