Experimental Neuroinflammation Laboratory
Our projects focus is to investigate the role of neuroinflammation in neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease and stroke.
Microglia are the major immune cells in the brain. Therefore, the majority of our projects aim to explore the function of these cells and to determine how they contribute to health and disease. In addition, we investigate how lifestyle-related factors, such as physical inactivity and stress, affect neuroinflammation and contribute to brain pathology.
Our research ranges from utilizing experimental models, such as in vitro microglia and in vivo mouse models, to conducting epidemiological investigations on the Swedish population. We combine traditional immunohistochemistry, ELISA, western blot, and animal behavioral tests with novel methods such as transcriptomics, proteomics, bioinformatics, and infrared spectroscopy.
- To elucidate the function of microglia-related genes and proteins, to find novel therapeutic targets.
- To understand how microglial cells interact with other cells in the brain.
- To identify early signs of neuroinflammation in neurodegenerative disorders.
- To investigate how systemic inflammation affects neuroinflammation.
- To clarify how lifestyle factors affect neuroinflammation and progression of disorders affecting the brain.
Understanding the role of neuroinflammation in neurodegenerative disorders opens up new therapeutic possibilities for early intervention and preventive strategies for patients at high risk of developing these diseases.
How our research contributes to the goals of MultiPark
Our projects aim at elucidating the early molecular and cellular mechanisms of pathogenesis in Alzheimer’s disease and microglia-related mechanisms in Parkinson’s disease. We address the aims of MultiPark's working group 1.
Research Team & Publications
Read about publications and research team members of the Experimental Neuroinflammation Laboratory research group in the LU Research Portal.
Skiers had lower incidence of depression and vascular dementia – but not Alzheimer’s Lund University news
Cross-country skiers suffer less depression and dementia Healthmedecinentral
January blues: cross-country skiers hold clues to beating it The Conversation
Long-Distance Skiers May Have "Motor Reserve" that Can Delay Onset of Parkinson's Disease Journal of Parkinson's disease
Researchers block protein that plays a key role in Alzheimer's disease World Pharma News
Skiing Cuts Vascular Dementia Risk in Half Alzheimer's & Dementia weekly
New findings on 'key players' in brain inflammation Science Daily
New findings on 'key players' in brain inflammation Technology Networks