Experimental Neuroinflammation Laboratory

Our research investigates molecular and cellular mechanisms underlying neurodegenerative diseases, particularly how neuroinflammation contributes to disease progression. In addition, we study physical exercise as prevention, following 1.4 million Swedes for up to 39 years to examine associations with neurodegenerative disease risk and subsequent progression.

We bridge fundamental discoveries with clinical relevance. By combining advanced imaging, omics, experimental models, and data-driven approaches, we identify pathways and therapeutic targets linking immune responses, metabolism, and neuronal dysfunction in Alzheimer’s and Parkinson’s disease. 

Our discovery of detrimental effects of microglial galectin-3 has inspired clinical trials targeting neuroinflammation through galectin-3 inhibition. Further, we found that early peripheral immune training can improve microglial responses to Alzheimer’s pathology. 

Taken together, our work contributes to an improved understanding of disease mechanisms, identification and development of targeted therapeutic strategies related to neuroinflammation and microglia processes. By integrating experimental and data-driven approaches, we aim to support earlier, more precise interventions in neurodegenerative diseases, directly aligning with MultiPark’s mission to understand, diagnose, and treat these conditions.