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Translational Neurotrauma group

Lund Brain Injury laboratory for Neurosurgical research

Our research

Traumatic brain injury (TBI) is a common cause of death and disability and current treatment options are limited. TBI is also a risk factor for neurodegeneration and dementias. Beta-amyloid (Aβ) and tau aggregations, hallmark findings of Alzheimer´s disease, are also observed in TBI. Therefore, we explore the link between TBI, aggregation of tau and A, and dementia.

Our research group study TBI, from the most severe injuries to the milder sport-related concussions (SRC), using experimental and clinical approaches. One important research aim is to enhance brain recovery following injury.

In addition, injury to axons leading to brain network dysfunction is the most significant cause of persisting behavioral problems in TBI/SRC. White matter injury, and its relation to neuroinflammation, is a key research area of our group where novel treatment options are being evaluated.

Aims

  • To study mechanisms of plasticity and repair following TBI and SRC.

  • To study mechanisms of tau and Aβ aggregation in experimental and clinical TBI and SRC.

  • To study the role of white matter and axonal injury in plasticity and neurodegeneration following TBI and SRC. 

  • To develop novel therapies, including anti-inflammatory drugs, that target plasticity, white matter injury and neurodegeneration following TBI and SRC.

Impact

We use novel neuroimaging (7T MRI, tau-PET), biomarkers, and neuropsychology in TBI patients and SRC athletes. Experimentally, we explore novel mechanisms and treatments in clinically- relevant models of TBI. TBI and SRC are important causes of death and persistent disability, and pose an increased risk for neurodegeneration. Our translational research is important to develop improved treatments.

How our research contributes to the goals of MultiPark

 Our research addresses the aim of MultiPark's working group 4. 


Research Team & Publications

Read about publications and research team members of the LUBIN Lab in the LU Research Portal. 

Profile photo of Niklas Marklund.
Photo: Mikael Wallerstedt

Niklas Marklund

Professor

niklas [dot] marklund [at] med [dot] lu [dot] se

Link to Niklas Marklund's profile in the LU Research Portal

Twitter: @LabLubin