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Drug Candidate Screening Platform

The drug candidate screening platform support researchers to identify and develop novel chemical tools to help you interrogate your particular field of interest. We contribute with +30 years of combined experiences from the pharmaceutical industry.

Services provided

  • Consultations within medicinal chemistry, chemical biology and drug discovery and development
  • Small molecule screening 

- assay development/optimization

- screening using in house libraries or from collaborators

- mechanism studies using pathway specific small molecule libraries

- guidance follow-up medicinal and synthetic chemistry 

- facilitate project transfer to/collaboration with other infrastructures

Resources CBCS Lund (BMC D10)

Agilent Bravo 96/384 format, volumes 1-70 mL application: screening, dose response etc.

Multidrop Combi 6 -1536 format, volumes 1-2500 mL application: dispersion of medium with and without cells, addition of reagents etc.

PlateLoc plate sealer for all types of microtiter plates

Tecan Spark Cyto plate reader with multimodal readout, 6-384 format (1536 fluorescence) Absorbance, fluorescence, luminescence Imaging 2/4/10x objectives using brightfield and fluorescence (blue, green, red, far-red)

In house small molecule library (8000 compounds) Annotated pathway/field specific libraries, approved drugs for repurposing, unannotated commercial libraries and natural product library

Access to other small molecule libraries through collaborations

Contact

 

Fredrik Ek
Researcher, Docent
e-mail:
fredrik [dot] Ek [at] med [dot] lu [dot] se (fredrik[dot]ek[at]med[dot]lu[dot]se)

Roger Olsson
Professor
e-mail:
roger [dot] olsson [at] med [dot] lu [dot] se (roger[dot]olsson[at]med[dot]lu[dot]se)