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MAXIV for sub-cellular X-ray

This group brings together researchers who want to use modern visualising methods to investigate molecular mechanisms at the sub-cellular level in neurodegenerative disorders. This includes, for example, high resolution, sub-cellular x-ray measurements to study molecular changes in cells or tissues to help identify the causes of the neurodegenerative diseases.

Overview of MAXIV equipment. Illustration.
MAXIV offers new techniques to unravel structural changes in biomolecules of interest to researchers in neurodegeneration.

Sweden has made significant strategic investments into national infrastructures like MAX IV, with world-unique instruments that can be used across disciplines. One emerging area is within medical sciences. Despite this potential, it is not an easy path to start using MAX IV-based techniques for many MultiPark researchers because they have not used these methods before and are not familiar with them.

Our special interest group wants to facilitate the usage of these state-of-the-art techniques that are just around the corner.

In alignment with MultiPark's strategic goals

To actively participate in the development of the MAX IV Laboratory and ESS for the benefit of both education and research by formulating biomedical problems that enable complex clinical applications is a central part of the strategic plan of the Faculty of Medicine and MultiPark.

Overarching goals

  • Make the MAX IV facility accessible to MultiPark members.
  • Expansion of knowledge about the service infrastructure that already exists at MultiPark towards the use of MAXIV

Planned activities

We focus on establishing a network to share knowledge on how MAXIV can help specific research and efficient preparation for using multiple spectromicroscopy techniques. Within the group, we plan to organise tri-monthly seminars open for all members of MultiPark to discuss spectroscopic imaging of cells and tissues at MAX IV related to in vitro microglia/inflammatory screening,  protein aggregation, synapse analysis, and neurophysiological properties, early microglia and neuronal dysfunction using correlative imaging methods to combine traditional brain imaging data with MAX IV generated data,  collaborative opportunities.

Convening person

Profile photo of Oxana Klementieva
Photo:Agata Garpenlind

Oxana Klementieva

Senior Lecturer

oxana [dot] klementieva [at] med [dot] lu [dot] se (oxana[dot]klementieva[at]med[dot]lu[dot]se)

Link to Oxana Klementieva's profile in the LU Research Portal