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New transnational collaboration to target circuit dysfunctions in Parkinson´s disease

The Basal Ganglia Pathophysiology research group has long experience in using established behavioral tests to monitor rodent behavior. This is used in combination with recordings of neuronal activity and molecular investigations with classical immunohistochemical methods. Photo: The Basal Ganglia Pathophysiology research group.
The Basal Ganglia Pathophysiology research group has long experience in using established behavioral tests to monitor rodent behavior. This is used in combination with recordings of neuronal activity. Copyright: The Basal Ganglia Pathophysiology group

A large collaborative project focused on understanding and treating dysfunctions of cortico-basal ganglia circuits in Parkinson´s disease (PD) has been awarded 35 million DKK from the Lundbeck Foundation. Angela Cenci Nilsson, coordinator of MultiPark, leads one of the three included research teams. Her group, the Basal ganglia pathophysiology, will conduct studies in animal models providing a basis for the development of novel approaches to non-invasive circuit modulation.

ADAPT-PD stands for ADAptive and Precise Targeting of cortex-basal ganglia circuits in Parkinson´s Disease. This project is a transnational collaboration, directed by Hartwig Siebner at the Danish Research Centre for Magnetic Resonance, Hvidovre. The research program spans from basic studies in experimental models to the clinical evaluation of novel treatment principles. The aim is to identify alterations in network dynamics causing motor and non-motor impairments in Parkinson´s disease (PD) and L-DOPA-induced dyskinesia. The gained knowledge will serve to develop precise approaches to circuit modulation. Professor Angela Cenci Nilsson will lead all preclinical investigations in rodent models.

Our final goal is to find optimal and precise targets for neuromodulation that are tailored to the needs of different patients.

“Our final goal is to find optimal and precise targets for neuromodulation that are tailored to the needs of different patients. We set the bar high in terms of anchoring potential new treatments to an understanding of what goes wrong in the brain during the evolution of PD. To reach this goal, it is essential to be able to mimic different types of symptoms in rodent models that are accessible to multiple levels of scientific investigation”, explains Angela Cenci Nilsson.

At Lund University, the Basal Ganglia Pathophysiology Unit will conduct advanced behavioral analyses in mouse models. This will be combined with brain-wide and single cell-resolved mapping of neural activity and optogenetic circuit manipulations. The project has just started and a post-doc position is available.

New postdoc position

START DATE: Any time from October 2021 through February-March 2022.

DURATION: 2-3 years.

Link to the Basal ganglia pathophysiology homepage.

Contact Angela Cenci Nilsson for more information.