Stem Cell Laboratory for CNS Disease Modeling

Our research

Research in the laboratory attempts to define pathogenic cellular and molecular mechanisms involved in synucleiopathies, in particular Parkinson's disease and multiple system atrophy, and Alzheimer's disease. Our work focuses on the interactions between glia and neurons. We are constantly developing new and robust human stem cell-based models which we utilize to understand cell autonomous and non-cell autonomous processes that lead to neuronal damage.

Aims

• To generate iPSCs from patients suffering familial and sporadic forms of the diseases, in order to elucidate causative mechanisms leading to neural cell dysfunction and neurodegeneration.

Impact

Our cutting-edge approach will allow for the identification of new molecular targets, which could be used for the development of new diagnostic tools for early diagnosis, as well as for the stratification and recruitment of patients for future clinical trials.

How our research contributes to the goals of MultiPark

Our research addresses the aims of MultiPark's working groups 1 and 4. 

Research Team & Publications

Read about publications and research team members of the Stem Cell Laboratory for CNS Disease Modeling in the LU Research Portal.