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Developmental and Regenerative Neurobiology

Our research

My group works with translational stem cell biology. The focus of my research is to understand cell fate specification in the developing brain and in human neural progenitor cells, using cell-based models of neuronal differentiation. Our current focus is to learn how to direct and efficiently drive controlled differentiation of human stem cells into subtype-specific neurons.

We also develop technologies for direct conversion of human fibroblasts into functional and subtype-specific neurons in vitro, and the conversion of endogenous glia into neurons in vivo. The ultimate aim is to develop these cells and technologies for use in brain repair, with a focus on Parkinson’s disease.

Aims

  • Develop a stem cell-based therapy for Parkinson’s Disease.
  • Use reprogramming to repair the brain.
  • Patient-specific treatments in Parkinson’s Disease.
  • Use cellular models to better understand and diagnose neurodegenerative diseases.

Impact

My vision is to create new, innovative, and evidence-based strategies for improved and novel treatments, disease-modifying therapies, and eventually cures for neurodegenerative diseases. The true opportunity of this work lies in the potential to deliver patient-specific treatments as well as curative stem cell-based therapies to patients globally.

How our research contributes to the goals of MultiPark

MultiPark’s vision is to create innovative approaches for the understanding, diagnosis, treatment, and eventually cures for neurodegenerative diseases. My work focus on cell repair and cell models which is central to these aims both for developing new therapies and for understanding and diagnosis disease. Our research addresses the aim of MultiPark's working group 2. 


Research Team & Publications

Read about publications and research team members of the Developmental and Regenerative Neurobiology in the LU Research Portal. 

Outreach

A selection of outreach in English, for a more complete list visit https://www.regenerative-neurobiology.lu.se/media-coverage

 

2019

Watch the video where Malin Parmar explains how Salamanders gives hope for new treatment of Parkinson's

www.youtube.com/watch?v=XnF1-4E3e6c&t=8s

Watch the lecture where Malin Parmar tells about the long history of transplantation trials in Lund and how they have been able to differentiate stem cells into specific dopaminergic cells in vitro.

https://www.youtube.com/watch?v=STuzZSxXv-I

Read about “How stem cells can help repair the brain” in Medical News Today

https://www.medicalnewstoday.com/articles/324472

 

2018

Watch an interview where Malin Parmar shares her insights and perspectives on gender equality during her research career.

https://www.youtube.com/watch?v=Up8k37w9oPo

 

2017

Malin tells about the process of transforming her research into the webcomics “A cell’s life”.

https://www.youtube.com/watch?v=LydRo3wluyQ

Enjoy the comics, based on Malin Parmars research, about how a skin cell can be turned into a neuron.  https://erccomics.com/comics/a-cells-life;

Malin Parmar's research group was involved in the creation of the "The invisible body" exhibition at the Sven-Harry's art museum in Stockholm.

https://www.sven-harrys.se/en/utforska/konsthallen/den-osynliga-kroppen/den-osynliga-kroppen

 

2016

Listen to when Malin Parmar talks about her research in BBC sounds https://www.bbc.co.uk/programmes/p047sw63,

 

2014

Listen to a podcast where Malin Parmar talks about her study published in Cell Stem Cell.

https://stemcellpodcast.com/ep32-parkinsons-cell-therapy-featuring-dr-malin-parmar

 

2013

Read about Malin Parmar’s research on “Making new neurons in a living brain” in National Geographic

https://www.nationalgeographic.com/science/article/making-new-neurons-in-a-living-brain

Watch a video where Malin Parmar explains how in vivo reprogramming may be a novel route to brain repair.

https://www.youtube.com/watch?v=LVQWjAwP9HY

 

2011

Listen to Malin Parmar talking about when she converted skin cells directly into neurons.

https://www.scienceupdate.com/2011/07/skin/

Profile photo of Malin Parmar

Malin Parmar

Professor

malin [dot] parmar [at] med [dot] lu [dot] se

Link to Malin Parmar's profile in the LU Research Portal

Twitter: @ParmarLab