Our research

Our research uses reprogramming strategies to generate interneurons from novel cell sources with the aim to extensively define the subtype and function of these for therapeutic development, e.g. via interneuron cell replacement. For this, we are using reprogramming technology in animal models or human stem cell culture systems, together with electrophysiology, RNA sequencing, tracing technologies, and cell-specific manipulation.

Interneurons are specific neuronal cells in the brain that are paramount for neural function. Loss or dysfunction of interneurons is implicated in several neurological disorders, but the specific neuronal pathology is not yet known mainly due to insufficient human disease models. Furthermore, interneuron cell therapy might provide an opportunity to tackling these neurological disorders.

Aims

• To generate subtype-specific interneurons from murine and human sources using neuronal reprogramming and assess the integration and function in vivo to assess the potential for cell replacement therapy. 
• To apply these protocols in vitro for human somatic cells from patients into interneurons for disease-modelling.

Impact

Our research will contribute to the further development of interneurons as a future cell therapy for brain disorders such as psychiatric diseases for which there currently is poor or no treatment.

Our projects will also bring significant insights into the interneuron-specific pathology in neurological disorders by establishing a patient-specific interneuron disease model.

How our research contributes to the goals of MultiPark

We run state-of-the-art facilities for studies of disease mechanisms, plasticity, and repair. Our work leads to the creation of new cellular and animal models that better reflect human disease. The studies also contribute to MultiPark’s goal to establish novel therapeutic approaches for developing more effective symptomatic, new disease-modifying and plasticity-enhancing treatments. Our research addresses the aim of MultiPark's working group 2. 

Research Team & Publications

Read about publications and research team members of the Regenerative Neurophysiology  in the LU Research Portal.