The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here:

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Medial Temporal Lab

Our research

Our research centers on aging and neurodegenerative diseases. We aim to gain a better understanding of underlying disease mechanisms and aid in the development of better biomarkers for disease progression and clinical trials.

We focus on characterizing the causes and effects of granular patterns of neurodegeneration, particularly in medial temporal lobe (MTL) subregions, which are selectively and early affected by neurodegenerative pathologies and might be good biomarkers. For this, we use structural MRI measures, but also imaging and biofluid markers.

Additionally, analysis of ex vivo material helps us to gain a better understanding of what we observe in living patients. For example, neurodegenerative pathology measures can be linked to structural MRI.

Moreover, we develop methods to accurately measure MTL subregions. Here, we take a rigorous approach going from ex vivo imaging to the development of manual segmentation protocols to the incorporation in automated algorithms.


  • To better characterize the drivers of neurodegeneration in the context of aging and dementia.
  • To develop biomarkers for clinical trials and clinical practice.
  • To improve structural measurements of medial temporal lobe subregions.


With our research, we aim to gain a better understanding of different neurodegenerative diseases. Our studies help to develop useful and sensitive biomarkers for clinical practice and clinical trials. Ultimately, this contributes to the development of treatments for different neurodegenerative diseases.

How our research contributes to the goals of MultiPark

 Our research addresses the aim of MultiPark's working group 6. 

Research Team & Publications

Read about publications and research team members of the Diagnostic Radiology in the LU Research Portal. 

Profile photo of Laura Wisse.
Photo: Ingrid Vogelaar

Laura Wisse

Senior Lecturer

laura [dot] wisse [at] med [dot] lu [dot] se (laura[dot]wisse[at]med[dot]lu[dot]se)

Link to Laura Wisse's profile in the LU Research Portal

Twitter: @lemwisse