Frontiers in Neuroscience Seminar Series
- 15 June, 16:00, Segerfalk Lecture Hall, A10
Einar M. Sigurdsson
Professor of Neuroscience & Physiology, and Psychiatry at New York University, USA
"Single domain antibodies for therapy and diagnosis of tauopathies and synucleinopathies"
My current research focuses on pathogenesis, therapy and diagnosis for age-related protein conformational disorders, in particular Alzheimer’s disease and more recently synucleinopathies. The scientific theme of my work is to study the disease-associated protein conformational alterations, their consequences at the molecular- and functional level, and the factors involved in this process. Most of my studies involve therapeutic targeting of this pathway and some include the development of diagnostic probes for in vivo detection of the protein aggregates involved in the pathogenesis of these diseases. I have a broad background in rodent models, including behavioral analyses, in related culture assays and mechanistic studies, and in developing therapeutic and diagnostic applications. As detailed below, I have a track-record of creativity, consistent productivity and significant scientific impact. I also have a record of professional service, including serving on numerous NIH study sections and successful mentoring of undergraduate, graduate and medical students, postdoctoral fellows and junior faculty – over 50 individuals to date, which includes several persons from diverse, underrepresented populations. Many of these individuals obtained grant support while in my lab and I served as a mentor on those proposals. Several of them are currently independent investigators within various universities and pharmaceutical companies or serve in executive function with these or other science-related firms.
Light refreshments will be served after the talk.
Host: Gunnar Gouras
Angela [dot] Cenci_Nilsson [at] med [dot] lu [dot] se (Angela Cenci-Nilsson), Gunnar [dot] Gouras [at] med [dot] lu [dot] se (Gunnar Gouras), Oskar [dot] Hansson [at] med [dot] lu [dot] se (Oskar Hansson), per [dot] odin [at] med [dot] lu [dot] se (Per Odin), tomas [dot] bjorklund [at] med [dot] lu [dot] se (Tomas Björklund)