Chemical Biology & Therapeutics

Our research

Organic Bioelectronic Neuropharmacology, electroceuticals for the nervous system - Our ambition is to supplement biochemical signaling with electronic functionalities using both galvanic (ion) and faradic (electron) processes.

Traditional medicines are based on biochemical principles without regard to electrical properties. We focus on organic electronics that are self-assembled directly inside or in the vicinity of the nervous system, to form electronic circuits that mimic the structure and organization of the nervous system, so that the nervous system can be seamlessly integrated.

A major challenge is to discover biocompatible materials that, with minimally invasive methods, can be integrated in-vivo to both electrically sense and actuate cells. As primary models for these studies, we use zebrafish and brain organoids with a focus on brain diseases and regenerative medicine.

Aims

• To explore and advance a field of neuropharmacology that modulates redox processes using galvanic and faradic processes.
• To design and synthesize organic bioelectronics that self-organize in-vivo.
• To explore the physics of organic bioelectronics materials.
• To evaluate organic bioelectronic materials in-vitro and in-vivo.
• To enter a clinical trial with an organic bioelectronic neuropharmacology concept.

Impact

We aim to develop a novel concept of neuropharmacology, to repair and modulate extracellular and intracellular redox processes as therapies for neurodegenerative diseases. Seamless integration of transient bioelectronic materials will repair post-mitotic neurons in the brain. This minimally invasive and site-specific methodology has the potential to provide brain repair to restore brain functions in patients.

How our research contributes to the goals of MultiPark

 Our research addresses the aim of MultiPark's working group 4. 

Research Team & Publications

Read about publications and research team members of the Chemical Biology & Therapeutics in the LU Research Portal.