Our research

We are interested in preclinical rodent models of neurodegenerative diseases with a focus on non-motor symptoms. We use these models to test treatments like cell replacement therapy and gene therapy. For that purpose, we use technologies that allow for the reversible manipulation of cell activity (opto- and chemogenetics), technologies that allow for the recording of neurotransmitter release at sub-second resolution (amperometry and chronoamperometry), as well as complex and automated behavioral assessment that taps into motor and non-motor domains.

Aims

• Develop and characterize animal models of neurodegenerative diseases.
• Assessment of non-motor symptoms in rodent models of Parkinson's disease (PD).
• Develop technologies that allow for demonstrating causal relationships between cell activity and behavior.

Impact

By understanding the mechanisms of repair and testing these in preclinical rodent models which more faithfully recapitulate the human condition we will make cell and gene therapy safer and more efficient.

How our research contributes to the goals of MultiPark

Our research addresses the aims of MultiPark's working groups 2,3 and 5. 

Research Team & Publications

Read about publications and research team members of the Behavioral neuroscience Laboratory in the LU Research Portal.