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Selected references

The following selected publications have used AAV vectors produced in our facility:

Aldrin-Kirk P, Heuer A, Wang G, Mattsson B, Lundblad M, Parmar M, Björklund T.
DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor.
Neuron. 2016 Jun 1;90(5):955-68. doi: 10.1016/j.neuron.2016.04.017. Epub 2016 May 5.


Wan OW, Shin E, Mattsson B, Caudal D, Svenningsson P, Björklund A
α-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter.
Sci Rep. 2016 May 23;6:26285. doi: 10.1038/srep26285. 


Tozzi A, de Iure A, Bagetta V, Tantucci M, Durante V, Quiroga-Varela A, Costa C, Di Filippo M, Ghiglieri V, Latagliata EC, Wegrzynowicz M, Decressac M, Giampà C, Dalley JW, Xia J, Gardoni F, Mellone M, El-Agnaf OM, Ardah MT, Puglisi-Allegra S, Björklund A, Spillantini MG, Picconi B, Calabresi P
Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit.
Biol Psychiatry. 2016 Mar 1;79(5):402-14. doi: 10.1016/j.biopsych.2015.08.013


Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Löfberg A, Jaarola M, Kugelberg UÖ, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Parkitna JR, Saper CB, Blomqvist A, Engblom D.
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice
J Clin Invest. 2016 Feb;126(2):695-705.


Malmevik J, Petri R, Knauff P, Brattås PL, Åkerblom M, Jakobsson J
Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons.
Sci Rep. 2016 Jan 27;6:19879. doi: 10.1038/srep19879.


Malmevik J, Petri R, Klussendorf T, Knauff P, Åkerblom M, Johansson J, Soneji S, Jakobsson J.
Identification of the miRNA targetome in hippocampal neurons using RIP-seq.
Sci Rep. 2015 Jul 28;5:12609. doi: 10.1038/srep12609.


Torper O, Ottosson DR, Pereira M, Lau S, Cardoso T, Grealish S, Parmar M
In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry.
Cell Rep. 2015 Jul 21;12(3):474-81. doi: 10.1016/j.celrep.2015.06.040.


Kopra J, Vilenius C, Grealish S, Härma MA, Varendi K, Lindholm J, Castrén E, Võikar V, Björklund A, Piepponen TP, Saarma M, Andressoo JO
GDNF is not required for catecholaminergic neuron survival in vivo.
Nat Neurosci. 2015 Mar;18(3):319-22. doi: 10.1038/nn.3941.


Decressac M, Kadkhodaei B, Mattsson B, Laguna A, Perlmann T, Björklund A
α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.
Sci Transl Med. 2012 Dec 5;4(163):163ra156. doi: 10.1126/scitranslmed.3004676.

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