Our research

We develop new microfluidic and acoustofluidic technology to create spatially and temporally controlled microenvironments for cell culturing and to manipulate biological matter in the microscale. This will provide new strategies for stem cell differentiation, novel means to study cell/tissue drug response, and new techniques for cell separation as well as submicron particle separation and manipulation, e.g. isolation and enrichment of extracellular vesicles.

Aims

• Develop novel microscale enrichment strategies for extracellular vesicle enrichment and purification.
• Understand the fundamental physics of particle/particle scattered sound interaction at nanometerscale.
• Develop acoustofluidic methods for differentiation of different extracellular subtypes.
• Develop optimized acoustophoresis based cell separation protocols by acoustophysically tuned buffer properties.
• Develop biomarker screening protocols based on extracellular vesicle proteome analysis.

Impact

Extracellular vesicles disseminated in blood and other biofluids carry biomolecular information about medical disorders. Being able to profile sub-proteomes of extracellular vesicles will open the route to access biobanks for extracellular vesicle-based biomarker discovery and hence pave the way for new diagnostic and predictive biomarkers as well as biomarkers for monitoring treatment response.

How our research contributes to the goals of MultiPark

We will provide new tools to better monitor and understand the origins and progression of neurodegenerative disease as well as to enable access to biomarkers that can better serve for diagnosis, prognosis, and to monitor treatment response and outcome.

Our research addresses the aim of MultiPark's working group 6.

Research Team & Publications

Read about publications and research team members of the Nanobiotechnology and Lab-on-a-chip in the LU Research Portal.