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Molecular signaling in neurodegenerative diseases

The Molecular Signaling Special Interest Group focus on genetics and their effects on different neurodegenerative disorders. Everything from gene expression, gene therapy, and epigenetic mechanisms is considered.

Neurons from the substantia Nigra pars compacta in red. Photo.
In substantia nigra, neurons expressing Calretinin seem to be more resistant to damage. Photo: Lautaro Belfiori.

This SIG combines a broad range of research topics. These include genetics, gene expression, gene therapy, and epigenetic mechanisms and their associated effects on different neurodegenerative and psychiatric disorders as well as brain tumors. We also consider the effect of ApoE genotype in the mechanisms involved in the degeneration observed in Alzheimer’s disease. Another focus is the development of new rodent models of cognitive deficits and impulse control disorders relevant to Parkinson’s disease. In addition to improving rodent models for translational research, we investigate maladaptive neuroplasticity associated with movement disorders.

In alignment with MultiPark's strategic goals

  • To create new therapeutic approaches for prevention, disease modification and management of unmet medical needs.
  • Support, develop, and run state-of-the-art facilities for studies of disease mechanisms, plasticity, and repair
  • Exploration of novel disease modifying therapeutic interventions.
  • Development of new cellular and animal models that better reflect human disease

Overarching goals

  • Strengthen the internal collaboration within MultiPark’s local environment, facilitating knowledge exchange between the groups.
  • Promote the use and access to technology exchange between the groups and with core facilities at MultiPark.

Planned activities

  • Start recurring “work in progress” meetings where the presenting person will show what they are working on and the state of their projects, including unfinished work or planned.

Convening person

Karolina Pircs. Photo.

Karolina Pircs

Associate senior lecturer

karolina [dot] pircs [at] med [dot] lu [dot] se (karolina[dot]pircs[at]med[dot]lu[dot]se) 

Link to Karolina Pircs' profile in the LU Research Portal