The drug candidate screening platform support researchers to identify and develop novel chemical tools to help you interrogate your particular field of interest. We contribute with +30 years of combined experiences from the pharmaceutical industry.

Services provided

• Consultations within medicinal chemistry, chemical biology and drug discovery and development
• Small molecule screening 

- assay development/optimization

- screening using in house libraries or from collaborators

- mechanism studies using pathway specific small molecule libraries

- guidance follow-up medicinal and synthetic chemistry 

- facilitate project transfer to/collaboration with other infrastructures

Resources CBCS Lund (BMC D10)

Agilent Bravo 96/384 format, volumes 1-70 mL application: screening, dose response etc.

Multidrop Combi 6 -1536 format, volumes 1-2500 mL application: dispersion of medium with and without cells, addition of reagents etc.

PlateLoc plate sealer for all types of microtiter plates

Tecan Spark Cyto plate reader with multimodal readout, 6-384 format (1536 fluorescence) Absorbance, fluorescence, luminescence Imaging 2/4/10x objectives using brightfield and fluorescence (blue, green, red, far-red)

In house small molecule library (8000 compounds) Annotated pathway/field specific libraries, approved drugs for repurposing, unannotated commercial libraries and natural product library. 

Access to other small molecule libraries through collaborations

Contact                                

Fredrik Ek or Roger Olsson 

BMC D10

Fredrik [dot] ek [at] med [dot] lu [dot] se (Fredrik[dot]ek[at]med[dot]lu[dot]se) or Roger [dot] olsson [at] med [dot] lu [dot] se (Roger[dot]olsson[at]med[dot]lu[dot]se)