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Selected references AAV


Klawonn A, Fritz M, Castany S, Pignatelli M, Similä F, Hugo AT, Levinsson J, Jaarola M, Hidalgo J, Jakobsson J, Heilig M, Bonci A, Engblom D.
Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons.
Immunity, 2021, 54: 225-234 

Itzia Jimenez-Ferrer, Michael Jewett, Alfredo Dueñas-Rey, Filip Bäckström, Antonio Boza-Serrano, Kelvin C. Luk, Tomas Deierborg and Maria Swanberg
The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease  OPEN ACCESS
Brain Behav Immun 91: 369-382, Jan 2021.

Hoban DB, Shrigley S, Mattsson B, Breger LS, Jarl U, Cardoso T, Nelander Wahlestedt  J, Luk  KC, Björklund A, Parmar M.
Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PDOPEN ACCESS
Proc Natl Acad Sci, USA, 2020 Jun 30;117(26):15209-15220.

Scheggi S, Rossi F, Corsi S, Fanni S, Tronci E, Ludovica C, Vargiu R, Gambarana C, Muñoz A, Stancampiano R, Bjorklund A, Carta M
BDNF Overexpression Increases Striatal D3 Receptor Level at Striatal Neurons and Exacerbates D1-Receptor Agonist-Induced Dyskinesia 
Journal of Parkinson's Disease, 08 July 2020

Brattås PL, Hersbach BA, Madsen S, Petri R, Jakobsson J, Pircs K
Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease.  OPEN ACCESS
Autophagy. 2020 May 6:1-14

Davidsson M, Wang G, Aldrin-Kirk P, Cardoso T, Nolbrant S, Hartnor M, Mudannayake J, Parmar M, Björklund T.
A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism.  OPEN ACCESS
Proc Natl Acad Sci U S A. 2019 Dec 9;116(52):27053-62.

Espa E, Clemensson EKH, Luk KC, Heuer A, Björklund T, Cenci MA.
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.
Mov Disord. 2019 Nov;34(11):1699-1710.

Rosenblad C, Li Q, Pioli EY, Dovero S, Antunes AS, Agúndez L, Bardelli M, Linden RM, Henckaerts E, Björklund A, Bezard E, Björklund T.
Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease.  OPEN ACCESS
Brain. 2019 Aug 1;142(8):2402-2416.

Tordo J, O'Leary C, Antunes ASLM, Palomar N, Aldrin-Kirk P, Basche M, Bennett A, D'Souza Z, Gleitz H, Godwin A, Holley RJ, Parker H, Liao AY, Rouse P, Youshani AS, Dridi L, Martins C, Levade T, Stacey KB, Davis DM, Dyer A, Clément N, Björklund T, Ali RR, Agbandje-McKenna M, Rahim AA, Pshezhetsky A, Waddington SN, Linden RM, Bigger BW, Henckaerts E.
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiencyOPEN ACCESS
Brain. 2018 Jul 1;141(7):2014-2031. 

Davidsson M, Díaz-Fernández P, Torroba M, Schwich OD, Aldrin-Kirk P, Quintino L, Heuer A, Wang G, Lundberg C, Björklund T.
Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing. OPEN ACCESS
RNA. 2018 May;24(5):673-687.

Aldrin-Kirk P, Heuer A, Rylander Ottosson D, Davidsson M, Mattsson B, Björklund T.
Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum.
Neurobiol Dis. 2018 Jan;109(Pt A):148-162.

Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Hult Lundh S, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA, Jakobsson J.
Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation  OPEN ACCESS
Cell Reports 24, 1397–1406, August 7, 2018

Michael Jewett, Elna Dickson, Kajsa Brolin, Matilde Negrini, Itzia Jimenez-Ferrer and Maria Swanberg
Gsta4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson's disease  OPEN ACCESS
Front Neurol. 2018 Apr 6; 9:222

Fieblinger T, Zanetti L, Sebastianutto I, Breger LS, Quintino L, Lockowandt M, Lundberg C, Cenci MA.
Striatonigral neurons divide into two distinct morphological-physiological phenotypes after chronic L-DOPA treatment in parkinsonian rats.   OPEN ACCESS
Sci Rep. 2018;8(1):10068.

Klawonn AM, Fritz M, Nilsson A, Bonaventura J, Shionoya K, Mirrasekhian E, KarlssonU, Jaarola M, Granseth B, Blomqvist A, MichaelidesM, Engblom D.
Motivational valence is determined by striatal melanocortin 4 receptorsOPEN ACCESS
J Clin Invest. 2018, 128: 3160-3170

Faustini G, Longhena F, Varanita T, Bubacco L, Pizzi M, Missale C, Benfenati F, Björklund A, Spano P, Bellucci A. Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.
Acta Neuropathol. 2018 Jul 25 

Aldrin-Kirk P, Heuer A, Wang G, Mattsson B, Lundblad M, Parmar M, Björklund T.
DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor. OPEN ACCESS
Neuron. 2016 Jun 1;90(5):955-68. 

Wan OW, Shin E, Mattsson B, Caudal D, Svenningsson P, Björklund A
α-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter.  OPEN ACCESS
Sci Rep. 2016 May 23;6:26285. 

Tozzi A, de Iure A, Bagetta V, Tantucci M, Durante V, Quiroga-Varela A, Costa C, Di Filippo M, Ghiglieri V, Latagliata EC, Wegrzynowicz M, Decressac M, Giampà C, Dalley JW, Xia J, Gardoni F, Mellone M, El-Agnaf OM, Ardah MT, Puglisi-Allegra S, Björklund A, Spillantini MG, Picconi B, Calabresi P
Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit.
Biol Psychiatry. 2016 Mar 1;79(5):402-14. 

Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Löfberg A, Jaarola M, Kugelberg UÖ, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Parkitna JR, Saper CB, Blomqvist A, Engblom D.
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice  OPEN ACCESS
J Clin Invest. 2016 Feb;126(2):695-705.

Malmevik J, Petri R, Knauff P, Brattås PL, Åkerblom M, Jakobsson J
Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons. OPEN ACCESS
Sci Rep. 2016 Jan 27;6:19879

Malmevik J, Petri R, Klussendorf T, Knauff P, Åkerblom M, Johansson J, Soneji S, Jakobsson J.
Identification of the miRNA targetome in hippocampal neurons using RIP-seq.  OPEN ACCESS
Sci Rep. 2015 Jul 28;5:12609. 

Torper O, Ottosson DR, Pereira M, Lau S, Cardoso T, Grealish S, Parmar M
In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry.  OPEN ACCESS
Cell Rep. 2015 Jul 21;12(3):474-81. doi: 10.1016/j.celrep.2015.06.040.

Kopra J, Vilenius C, Grealish S, Härma MA, Varendi K, Lindholm J, Castrén E, Võikar V, Björklund A, Piepponen TP, Saarma M, Andressoo JO
GDNF is not required for catecholaminergic neuron survival in vivo.  OPEN ACCESS
Nat Neurosci. 2015 Mar;18(3):319-22. doi: 10.1038/nn.3941.

Decressac M, Kadkhodaei B, Mattsson B, Laguna A, Perlmann T, Björklund A
α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.   OPEN ACCESS
Sci Transl Med. 2012 Dec 5;4(163):163ra156.