Frontiers in Neuroscience seminar: "Neural progenitors in the subventricular zone of Parkinson patients"

Welcome to a lecture by our guest speaker Elly Hol, professor of “Glia biology of brain diseases”, at Utrecht University who will talk about "Neural progenitors in the subventricular zone of Parkinson patients".

The lecture will address the following topics:

• A splice-variant of GFAP, GFAPdelta, is a marker for human neural progenitors in the human developing and adult subventricular zone.
• Neural stem cells from elderly individuals and Parkinson patients form neurospheres and can be differentiated into neurons and glia in vitro.
• Ventricular cerebrospinal fluid increases neural progenitor proliferation and continues to stimulate neural progenitors throughout aging.
• Parkinson neural progenitors show significant changes at both transcriptome and proteome compared to neurological controls.
• Our transcriptomic and proteomic data suggest that the progenitors transit into a primed-quiescent state, that is in an "alert" non-proliferative phase in Parkinson.
• Single cell profiling of adult human neural progenitors identifies SFRP1 as a target to re-activate progenitors

Host: Angela Cenci Nilsson